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Viral Vectors Gene Therapy and Neuroscience Applications

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Published by Academic Press .
Written in English


  • Mammals,
  • Medical Genetics,
  • Neurology & clinical neurophysiology,
  • Neurology - General,
  • Infectious Diseases,
  • Diseases Of Central Nervous System,
  • Viruses,
  • Medical / Nursing,
  • Medical,
  • Life Sciences - Biochemistry,
  • Neuroscience,
  • Medical / Neuroscience,
  • Diseases,
  • Central nervous system,
  • Gene therapy,
  • Genetic vectors

Book details:

Edition Notes

ContributionsMichael G. Kaplitt (Editor), Arthur D. Loewy (Editor)
The Physical Object
Number of Pages486
ID Numbers
Open LibraryOL9282331M
ISBN 100123975700
ISBN 109780123975706

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In Viral Vectors for Gene Therapy: Methods and Protocols, experts in the field present a collection of their knowledge and experience featuring methodologies that involve virus production, transferring protocols, and evaluating the efficacy of gene products. While thoroughly covering the most popular viral vector systems of adenovirus, retrovirus, and adeno-associated virus, this detailed volume also explores less common viral vector Price: $ Viral Vectors: Gene Therapy and Neuroscience Applications represents the first comprehensive review of viral vector applications to the nervous system by leaders in virology, molecular neurobiology, neuroanatomy, and developmental neurobiology. It serves both as a source of fundamental information for those newly interested in viral vectors and as a compilation of . Viral Vectors for Gene Therapy: Methods and Protocols consists of 30 ch- ters detailing the use of herpes viruses, adenoviruses, adeno-associated viruses, simple and complex retroviruses, including lentiviruses, and other virus systems for vector . Basic Concepts in Viral Vector-Mediated Gene Therapy Matthew J. Benskey, Ivette M. Sandoval, Kathryn Miller, Rhyomi L. Sellnow, Aysegul Gezer, Nathan C. Kuhn et al. Pages Novel Modes of Gene Therapy (Going Beyond Overexpression and Knockdown).

A detailed comparison of the viral and nonviral vectors is presented. The chapter also describes the cytoplasmic expression and hybrid viral and nonviral vectors. The discussion concludes with the hope that exploiting gene therapy for medical modalities would become a . An important general consideration in the design of retroviral vectors is the effect of viral replication on vector structure. After one round of viral replication, the U3 regions in both LTRs are derived from the U3 region originally present in the 3′LTR in the plasmid form of the vector, and both U5 regions are derived from the U5 region Cited by: 5. production of viral vectors. In the follow-ing, cell culture technologies and processes are described, focusing on their use for the specific production of viral vectors. Depend-ing on the amount of the viral vector to be produced as well as of the cell system used, different culture systems are available for the production of viral by: Viral Vectors. All viruses attack their hosts and introduce their genetic material into the host cell as part of their replication cycle. This genetic material contains basic 'instructions' of how to produce more copies of these viruses, hijacking the body's normal production machinery to serve the needs of the virus (see figure 1).

Nanoparticle Coated Viral Vectors for Gene Therapy Author(s): Ruchita Selot, Srujan Marepally, Praveen Kumar Vemula, Giridhara R. by: 2. Comprehensive and practical, Viral Vectors for Gene Therapy: Methods and Protocols provides basic principles accessible to scientists from a wide variety of backgrounds for the development of gene therapy viral products that are safe and effective. Viral vectors: A look back and ahead on gene transfer technology February The New Microbiologica: official journal of the Italian Society for Medical Virology (SIVIM) 36(1) Plant Viral Vectors. by. Current Topics in Microbiology and Immunology (Book ) Share your thoughts Complete your review. Tell readers what you thought by rating and reviewing this book. Rate it * You Rated it *Brand: Springer Berlin Heidelberg.